Grants Awarded to CancerFree KIDS

The following are grants awarded recently to CFK. Each grant makes possible important programs that are needed to enhance the impact we are making in our mission. CancerFree KIDS is very grateful for the generosity of these foundations!

Greater Cincinnati Foundation
$11,735 for the purchase of much needed development software for the CFK Office. The Elizabeth B. Lips Memorial Fund and the Selma Rabkin Schneck Family Fund were the sources of the grant.

The Lois and Melba Schott Foundation
Fifth Third Bank Trustee - $20,000 for the establishment and development of a CFK Affiliate program. The purpose of the Affiliate program is to engage the support of families who have lost children to cancer, and who wish to support the mission of CancerFree Kids by hosting their own event in memory of their child.

The Wohlgemuth Herschede Foundation
Fifth Third Bank Trustee - $5000 to be used specifically for pediatric cancer research. Allocation of this money will be made at the recommendation of the CFK Grant Selection Committee.

Thank you!

CancerFree KIDS extends its thanks to Modern Office Methods for their generous gift of a new copier for the CFK office!

Grants Awarded by CancerFree KIDS for Research

2004 — $20,000 Grants Awarded:

• $10,000: Improving Donor Selection in Bone Marrow Transplantation (Mehta)
• $10,000: Development of a Novel Anti-Neuroblastoma Agent (Qi)

2005 — $40,000 Grants Awarded:

• $10,000: Molecular Mediators of Childhood T Cell Leukemia (Layh-Schmitt)
• $10,000: The Role of Rac GTPases in Leukemias (Shore)
• $10,000: Assessment of MGMT as a Therapeutic Target for Neuroblastoma (Wagner)
• $10,000: Identification of the Genes Regulated by Leukemia Fusion Proteins and the Role they play in Leukemia Development (Mulloy)

2006 — $80,000 Grants Awarded:

• $20,000: A New Drug Target for T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (Horman/Grimes)
• $20,000: Squamous Cell Carcinoma in Children with Epidermolysis Bullosa (Adams)
• $20,000: Musculoskeletal Tumor Center Tissue Repository (Cripe)
• $20,000: Micro RNA Expression in Neuroblastoma (Jansen/Davies)

2007 — $100,000 Grants Awarded:

• $20,000: Immune System Evasion by Cancer (Researcher: Michael B. Jordan, MD)
• $20,000: Targeting Leukemia Stem Cells (Researchers: Shane Horman, Ph.D., Philip Roehrs, M.D., and H. Leighton Grimes, Ph.D.)
• $20,000: How the RB Protein contributes to progression of Lymphoblastic Leukemia (Researcher: Hartmut Geiger, M.D.)
• $20,000: Identification of New Mini-Molecules (microRNAs) Causing Pediatric Lymphomas After Transplantation and new Targets for Therapy (Researchers: Michael Absalon, MD, Ph.D, and John Perentesis, MD)
• $20,000: New Drug Discovery for Treatment of High Risk Neuroblastoma (Researchers: John Perentesis, MD and Gretchen Radloff, MS)

2008 — $160,000 Grants Awarded:

• Dr. Cripe: $25,000 - Identifying and targeting the source of neuroblastoma metastasis.
• Dr. Geiger: $40,000 - The role of the RB protein in leukemia progression.
• Dr. Wagner: $20,000 - Identification of response markers in children receiving combination therapy with chemotherapy and bevacizumab.
• Dr. Browne: $35,000 - Delivery and production of a secretable universal cancer biomarker and its detection in the blood by a novel continuous sampling microtechnology.
• Dr. Li/Dr. Perentesis: $40,000 - Personalized neuroblastoma cancer signatures and targeted therapy.

2009 — $180,000 Grants Awarded:

• Dr. Rachid Drissi in collaboration with Dr. Cripe - Decreasing the Side Effects of Radiation Therapy for Cancer
• Dr. Maryam Fouladi in collaboration with Drs. Aranow and Ratner - Molecular Profiling of High-Grade Gliomas in Children
• Dr. Jason Frischer - Developing a "Triple Threat" Treatment of a Neuroblastoma Model (Recipient of the Butterfly Walk Research Grant)
• Dr. Lee Grimes - A Potential Cure for Acute Myeloid Leukemia
• Dr. Benjamin Mizukawa - Chemosensitization of the Leukemic Stem Cell through Targeting Its Interaction with the Marrow Niche

2010 — $225,000 Grants Awarded

• Dr. Kumar: $20,000 - A novel targested therapy for infant leukemia
• Dr. Grimes: $20,000 - Nanoparticles with siRNA therapy
• Dr. Sumegi: $20,000 - Epigenetic control of tumorigenesis in Ewing’s Sarcoma family of tumors
• Dr. Cancelas: $20,000 - Vav as a molecular target in pediatric acute lymphoblastic leukemia
• Dr. Dasgupta: $20,000 - Inhibition of Pediatric Brainstem Glioma by genetic inhibition of AMP Kinase
• Dr. Geller: $40,000 - A pilot trial of catheter assisted delivery of intra-opthalmic artery chemotherapy of retinoblastoma
• Dr. Chou: $40,000 - A preclinical trial of targeting the self-renewal pathway to eradicate leukemic stem cells
• Dr. Wang: $45,000 - Virotherapy of neuroblastoma stem cells

Total: $225,000

Grants to be awarded in March, 2011: $200,000

Grant application information can be provided by calling (513) 575-5437